Curated News: NEJM

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Avian influenza A(H5N1) virus, which spread to cattle and infected 14 people this year, was detected using virome sequencing in the wastewater of 10 Texas cities by researchers at UTHealth Houston and Baylor College of Medicine.

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A brain-computer interface developed by UC Davis Health accurately translates brain signals into speech. The device implanted in the brain of a man with ALS is the most accurate system of its kind.

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A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA). The promising new drug stems from a 2008 genetic discovery made at the Johns Hopkins Kimmel Cancer Center.

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When it comes to caring for children with congenital adrenal hyperplasia (CAH), avoiding the side effects of traditional treatments has long been a challenge. But in a recent phase 3 clinical trial, a new drug called crinecerfont showed safety and efficacy in children with classic CAH, the severe form of this condition.

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En un nuevo estudio multicéntrico internacional dirigido por el Centro Oncológico Integral de Mayo Clinic, investigadores encontraron que las personas con el subtipo de leucemia linfoblástica aguda precursores de células B (LLA-BCP), que tampoco presentaban una anomalía genética conocida como cromosoma Filadelfia y que estaban en remisión y sin rastros de cáncer, mostraron tasas de supervivencia significativamente más altas cuando se agregó blinatumomab al tratamiento de quimioterapia.

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Em um novo estudo multicêntrico internacional liderado pelo Centro Oncológico Integral da Mayo Clinic, pesquisadores descobriram que pessoas com o subtipo de leucemia linfoblástica aguda de precursor de células B (LLA-BCP), que também não apresentavam uma anomalia genética conhecida como cromossomo Filadélfia e que estavam em remissão e sem vestígios de câncer, mostraram taxas de sobrevivência significativamente mais elevadas quando o blinatumomab foi adicionado ao tratamento quimioterápico.

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In a new multicenter international study led by the Mayo Clinic Comprehensive Cancer Center, researchers found that people with the B-cell precursor subtype of acute lymphoblastic leukemia (BCP-ALL), who also lacked a genetic abnormality known as the Philadelphia chromosome and were in remission with no trace of cancer, showed significantly higher survival rates when blinatumomab was added to their chemotherapy treatment.

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The risk of long COVID has declined over the course of the pandemic, although it remains a persistent threat. Researchers from Washington University School of Medicine in St. Louis identified vaccination as a primary factor in reducing the risk of long COVID.

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Bakris served on the UChicago faculty for 18 years and was director of the Comprehensive Hypertension Center.

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The data fed to artificial intelligence (AI) systems make all the difference on performance, according to David Ouyang, MD, a cardiologist in the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai.

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Patients with moderate to severe treatment-resistant depression (TRD) might have better symptom relief from ketamine infusions than from electroconvulsive therapy (ECT), but those with severe TRD could benefit more from ECT early in treatment, an analysis led by a UT Southwestern Medical Center researcher shows. The findings, published in JAMA Network Open, are the first to identify characteristics that distinguish which treatments might benefit TRD patients more.

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UC San Diego School of Medicine international study shows new drug improves sleep, health in patients diagnosed with obesity and sleep apnea.

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Critically ill patients are at risk of stress-induced upper gastrointestinal bleeding. Now, a global trial led by McMaster University researchers confirms that a widely available drug does prevent upper gastrointestinal bleeding.

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A new detailed analysis of a patient’s second cancer after receiving CAR-T therapy for the initial cancer provides rare but important insights intended to offer helpful guidance for oncologists and pathologists about the clinical presentation and pathologic features involved in a CAR-T related second cancer.

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In a large clinical trial, UT Southwestern Medical Center researchers developed a robust model for testing strategies to prevent health problems in patients with multiple chronic conditions.

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A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different types of cholesterol and triglycerides in individuals with mixed hyperlipidemia, a condition in which fats build up in the blood.