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Feature Channels: Clinical Trials

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Newswise:Video Embedded expanding-a-dynamic-surgery-department
VIDEO
Released: 1-May-2023 6:35 PM EDT
Expanding a Dynamic Surgery Department
Cedars-Sinai

Cedars-Sinai recently appointed distinguished surgical oncologist Cristina Ferrone, MD, as chair of the Department of Surgery.

Newswise: Clinical Trials by Desai Sethi Urology Institute Researchers Simultaneously Presented at AUA and Published in Journal of Urology
Released: 1-May-2023 5:10 PM EDT
Clinical Trials by Desai Sethi Urology Institute Researchers Simultaneously Presented at AUA and Published in Journal of Urology
University of Miami Health System, Miller School of Medicine

Novel research in sexual health by investigators at the Desai Sethi Urology Institute (DSUI) at the University of Miami Miller School of Medicine was presented at the 2023 American Urological Association (AUA), one of the world's most important urology meetings, and simultaneously published in, the Journal of Urology, one of the highest impact journals in the specialty.

   
Newswise: April Research Highlights
Released: 28-Apr-2023 4:50 PM EDT
April Research Highlights
Cedars-Sinai

A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for April 2023.

Newswise: New Study Looks at Role of Sleep Disruption in Dogs With Dementia
Released: 28-Apr-2023 10:30 AM EDT
New Study Looks at Role of Sleep Disruption in Dogs With Dementia
North Carolina State University

Dogs with dementia suffer the same sleep disruptions that humans with dementia do.

Released: 27-Apr-2023 3:00 PM EDT
ATS 2023 International Conference Announces Late-Breaking Clinical Trials
American Thoracic Society (ATS)

One of the most highly-anticipated events at the ATS 2023 International Conference, which kicks off May 19, is the “Breaking News: Clinical Trial Results in Pulmonary Medicine.” Taking place on Monday, May 22, the series of presentations will focus on the latest regarding COPD and asthma treatment.

Released: 27-Apr-2023 2:30 PM EDT
Society for Clinical Trials Presents CHAP Trial with Prestigious David Sackett Trial of the Year Award
Society for Clinical Trials

The Society for Clinical Trials (SCT) is pleased to announce that the prestigious David Sackett Trial of the Year Award will be presented to The Chronic Hypertension and Pregnancy (CHAP) Trial.

Released: 27-Apr-2023 9:00 AM EDT
Susan G. Komen® Welcomes Nine Leaders to Research Advisory Roles
Susan G. Komen

Susan G. Komen®, the world’s leading breast cancer organization, has appointed nine world-renowned medical and research experts to serve as advisors to the organization. These breast cancer experts will be part of a distinguished group, known as Komen Scholars, who help guide Komen’s research and scientific programs, with a focus on advancing discoveries to improve breast cancer outcomes for everyone.

Released: 25-Apr-2023 6:05 PM EDT
Precision eye therapy for dogs ready for human clinical development
Michigan State University

A successful gene therapy trialed at Michigan State University in dogs with an inherited eye disease is ready to be developed for clinical use in human patients with a rare condition called retinitis pigmentosa.

Released: 25-Apr-2023 2:00 PM EDT
First-Ever Randomized Clinical Trial Using ACS NSQIP Data Shows Reduction in Surgical Site Infections
American College of Surgeons (ACS)

First-ever randomized clinical trial linked to registry data from ACS NSQIP published in JAMA.

Released: 24-Apr-2023 6:05 PM EDT
UCLA Health seeks participants for first-of-its-kind study using injectable buprenorphine to treat methamphetamine use disorder and opioid co-use
University of California, Los Angeles (UCLA), Health Sciences

UCLA Health investigators are leading a new, six-city trial of injectable buprenorphine for treatment of methamphetamine use disorder in adults who also use opioids.

Newswise:  UT Southwestern, Children’s Health to lead clinical trial on pediatric cancer patients
Released: 24-Apr-2023 11:05 AM EDT
UT Southwestern, Children’s Health to lead clinical trial on pediatric cancer patients
UT Southwestern Medical Center

UT Southwestern Medical Center will lead a national multicenter clinical trial to test a treatment strategy for pediatric cancer patients that has shown promising results in adults. The trial will examine the effects of combining several chemotherapy agents with an immunotherapy drug in children with solid tumors that have recurred or shown no significant response after initial treatment.

Released: 21-Apr-2023 7:05 PM EDT
Surgery most effective treatment of metabolic liver disease
King's College London

Metabolic (bariatric) surgery is more effective than medications and lifestyle interventions for the treatment of advanced non-alcoholic fatty liver disease.

Newswise:Video Embedded live-event-for-april-21-sleeping-pill-reduces-levels-of-alzheimer-s-proteins
VIDEO
Released: 21-Apr-2023 3:10 PM EDT
TRANSCRIPT AND VIDEO AVAILABLE Live Event for April 21: Sleeping pill reduces levels of Alzheimer’s proteins
Newswise

Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.

       
Newswise: Lack of Women as Research Subjects Connected to Lack of Women as Researchers
12-Apr-2023 4:10 PM EDT
Lack of Women as Research Subjects Connected to Lack of Women as Researchers
American Physiological Society (APS)

The underrepresentation of female research subjects has been documented from clinical trials down to sources for cell cultures. Now, researchers out of Marquette University in Milwaukee have found that in exercise research, this inequity correlates with the gender of the researchers conducting the study.

   
19-Apr-2023 4:35 PM EDT
Cancer survivor gives $10 million to speed translational research and clinical trials
University of Texas MD Anderson Cancer Center

Vijay Goradia, a Houston-based businessman, philanthropist, and cancer survivor, has donated $10 million to The University of Texas MD Anderson Cancer Center to speed translational research and clinical trials.

Released: 19-Apr-2023 2:15 PM EDT
Clinical trial begins using CAR T cells to potentially cure HIV
UC Davis Health

UC Davis Health researchers have dosed the second participant in their clinical trial looking to identify a potential cure for HIV utilizing CART-cell therapy.

Released: 19-Apr-2023 12:00 PM EDT
MD Anderson Research Highlights for April 19, 2023
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

   
Newswise: NIH Trial Evaluating Mpox Vaccine in Adolescents
Released: 19-Apr-2023 9:30 AM EDT
NIH Trial Evaluating Mpox Vaccine in Adolescents
George Washington University

The National Institutes of Health trial to evaluate the mpox (previously known as monkeypox) vaccine JYNNEOS has now entered the next stage and is studying the immune responses to and the safety of the vaccine in adolescents. The George Washington University is one of 18 clinical trial sites across the United States that have launched this stage testing the JYNNEOS vaccine.

Released: 18-Apr-2023 3:05 PM EDT
Immunotherapy Drug Development Pipeline Shifts from Traditional Therapies to Newer Modalities
Cancer Research Institute

The immuno-oncology (IO) clinical trial landscape is shifting in new directions. While the number of total clinical trials is down, there are healthy signs of innovation.

Newswise: AACR: Early trial results show benefits of FGFR inhibitors and PARP/ATR inhibitor combinations in multiple tumor types
14-Apr-2023 12:05 PM EDT
AACR: Early trial results show benefits of FGFR inhibitors and PARP/ATR inhibitor combinations in multiple tumor types
University of Texas MD Anderson Cancer Center

Researchers from The University of Texas MD Anderson Cancer Center presented promising findings from multiple clinical trials today at the American Association for Cancer Research (AACR) Annual Meeting 2023. The studies, which describe results from a novel FGFR inhibitor and from new PARP/ATR inhibitor combinations, were featured in a plenary session highlighting novel biomarker-driven molecularly targeted therapy trials.

Released: 18-Apr-2023 10:05 AM EDT
FTD/TPI Plus Oxaliplatin Well-Tolerated But Not Broadly Effective as Treatment for Esophageal Cancer
Roswell Park Comprehensive Cancer Center

Research led by Roswell Park's Sarbajit Mukherjee, MD, MS, shows that a new chemotherapy combination — trifluridine/tipiracil (FTD/TPI) and oxaliplatin — is well tolerated and has activity among patients with esophageal cancer.

Released: 17-Apr-2023 1:40 PM EDT
IU cancer center researcher leads first in-human multiple myeloma study with 90.5 percent response rate
Indiana University

Indiana University Melvin and Bren Simon Comprehensive Cancer Center served as the lead site for a promising first-in-human clinical trial for patients with relapsed multiple myeloma. Patients treated with higher doses of the immunotherapy called REGN5459 resulted in a 90.5 percent overall response rate.

Released: 17-Apr-2023 11:05 AM EDT
Leaps in artificial blood research aim to improve product safety, efficacy
Ohio State University

Researchers have made huge strides in ensuring that red blood cell substitutes – or artificial blood – are able to work safely and effectively when transfused into the bloodstream.

Newswise: Investigational drug may improve stem cell transplantation for multiple myeloma patients
14-Apr-2023 11:05 AM EDT
Investigational drug may improve stem cell transplantation for multiple myeloma patients
Washington University in St. Louis

An international phase 3 clinical trial led by physicians at Washington University School of Medicine in St. Louis has shown that the investigational drug motixafortide — when combined with the standard therapy for mobilizing stem cells — significantly increases the number of stem cells that can be harvested, compared with treatment with the standard agent alone.

14-Apr-2023 7:00 AM EDT
AACR: Novel allogeneic CAR T cell therapy delivers promising early results in patients with metastatic clear cell renal cell carcinoma
University of Texas MD Anderson Cancer Center

The CD70-targeting allogeneic chimeric antigen receptor (CAR) T cell therapy, ALLO-316, demonstrated encouraging response rates and disease control rates in patients with metastatic clear cell renal cell carcinoma (ccRCC), according to results of a Phase I trial led by researchers at The University of Texas MD Anderson Cancer Center and presented today at the American Association for Cancer Research (AACR) Annual Meeting 2023.

Newswise: AACR: YAP/TEAD inhibitor VT3989 is well tolerated and shows antitumor activity in advanced mesothelioma and NF2-mutant cancers
14-Apr-2023 12:00 PM EDT
AACR: YAP/TEAD inhibitor VT3989 is well tolerated and shows antitumor activity in advanced mesothelioma and NF2-mutant cancers
University of Texas MD Anderson Cancer Center

The first-in-class YAP/TEAD inhibitor VT3989 was well tolerated with durable antitumor responses in patients with advanced malignant mesothelioma and other tumors with NF2 mutations, according to results of a Phase I trial led by researchers at The University of Texas MD Anderson Cancer Center.

14-Apr-2023 12:00 PM EDT
AACR: Penn Medicine Preclinical Study Identifies New Target for Recurrent Ovarian Cancer
Perelman School of Medicine at the University of Pennsylvania

Results from a preclinical study from Penn Medicine, presented at the AACR Annual Meeting 2023, verified a new target for drug-resistant ovarian cancer and provided data to support a treatment approach that is already making its way into clinical trials.

Newswise: AACR: Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery
13-Apr-2023 3:40 PM EDT
AACR: Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery
University of Texas MD Anderson Cancer Center

A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to Phase III trial results presented today by researchers from The University of Texas MD Anderson Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2023.

Released: 14-Apr-2023 9:45 AM EDT
Rutgers Launches Lyme Disease Vaccine Study
Rutgers University-New Brunswick

The university is participating in the effort to determine the efficacy of what could be the first vaccine to prevent Lyme disease in children ages 5 to 17

Released: 13-Apr-2023 5:25 PM EDT
Prestigious New England Journal of Medicine Publishes Ochsner Health’s Research into Alternative to Amputation
Ochsner Health

Ochsner Health is one of 20 sites in the U.S. participating in the PROMISE II clinical trial, which was recently published in the New England Journal of Medicine.

Released: 13-Apr-2023 2:40 PM EDT
Sex of blood donor has no effect on recipient survival
Ottawa Hospital

A large clinical trial of more than 8,700 patients published in the New England Journal of Medicine concluded that the sex of a donor has no effect on the survival of recipients of red blood cell transfusions.

Newswise: UCSF Interventional Cardiologists Perform Novel Investigative Tricuspid Valve Procedure
Released: 13-Apr-2023 8:00 AM EDT
UCSF Interventional Cardiologists Perform Novel Investigative Tricuspid Valve Procedure
University of California, San Francisco (UCSF)

UC San Francisco interventional cardiologists and interventional echocardiographers recently performed two novel minimally invasive cardiac procedures for the first time in the health system.

Newswise: Cedars-Sinai Cancer Collaborates on a New Type of Clinical Trial
Released: 12-Apr-2023 12:45 PM EDT
Cedars-Sinai Cancer Collaborates on a New Type of Clinical Trial
Cedars-Sinai

Investigators from Cedars-Sinai Cancer are collaborating on a streamlined clinical trial design in a study called Pragmatica-Lung.

12-Apr-2023 10:05 AM EDT
Open-label placebo improved outcomes for people in treatment for opioid use disorder
Beth Israel Deaconess Medical Center

Researchers tested whether using open-label placebo could increase the efficacy of methadone treatment for people undergoing care for opioid use disorder.

Newswise: VUMC-Led Trial Shows Two Investigational Drugs Are Ineffective for Treating Severe COVID-19
Released: 11-Apr-2023 12:00 PM EDT
VUMC-Led Trial Shows Two Investigational Drugs Are Ineffective for Treating Severe COVID-19
Vanderbilt University Medical Center

A study published April 11 in the Journal of the American Medical Association (JAMA) evaluated two drugs that act on the renin-angiotensin system (RAS) as potential treatments for severe COVID-19. Severe acute respiratory syndrome coronavirus2 (SARS-CoV-2), the virus that causes COVID-19, enters pulmonary and myocardial cells through binding of its spike protein to the human angiotensin-converting enzyme 2 (ACE2). ACE2 is a vital enzyme that controls blood pressure and blood flow to multiple organs, including the lungs, heart and kidneys.

Released: 11-Apr-2023 6:00 AM EDT
Pesquisa descobre que pacientes com diversos tumores em um seio podem não precisar de mastectomia
Mayo Clinic

De acordo com uma pesquisa conduzida pela Aliança para Ensaios Clínicos em Oncologia e o Centro de Câncer da Mayo Clinic, pacientes com diversos tumores em um seio podem ser capazes de evitar uma mastectomia se os tumores puderem ser removidos enquanto uma quantidade suficiente de tecido mamário puder ser preservada.

Released: 11-Apr-2023 6:00 AM EDT
توصل بحث إلى أن النساء المصابات بأورام متعددة في أحد الثديين قد لا يضطررن إلى استئصاله.
Mayo Clinic

قد تتمكن النساء المصابات بأورام متعددة في أحد الثديين من تجنب استئصاله إذا أمكن استئصال هذه الأورام مع الاحتفاظ بأنسجة ثدي كافية، وذلك وفقًا لبحث قاده التحالف الطبي للتجارب السريرية في علم الأورام ومركز مايو كلينك الشامل للسرطان.

Released: 11-Apr-2023 6:00 AM EDT
Una investigación indica que las pacientes con varios tumores en una sola mama podrían no necesitar una mastectomía
Mayo Clinic

De acuerdo con la investigación dirigida por la Alianza para Ensayos Clínicos en Oncología y el Centro Oncológico Integral de Mayo Clinic, las pacientes que tengan varios tumores en una sola mama podrían evitar una mastectomía si los tumores se pueden extraer dejando bastante tejido mamario.

Newswise: Yale Cancer Center experts to present new research at annual AACR Meeting
Released: 10-Apr-2023 7:05 AM EDT
Yale Cancer Center experts to present new research at annual AACR Meeting
Yale Cancer Center/Smilow Cancer Hospital

Yale Cancer Center (YCC) and Smilow Cancer Hospital (SCH) physicians and scientists are presenting research studies at the 2023 American Association for Cancer Research (AACR) Annual Meeting at the Orange County Convention Center in Orlando, Florida, April 14 to 19th.

Released: 7-Apr-2023 6:05 PM EDT
Creating method for scoring pancreatic cancer patients for surgery
Translational Genomics Research Institute (TGen)

A trio of premier Southwest biomedical research centers — HonorHealth Research Institute, City of Hope and the Translational Genomics Research Institute (TGen), part of City of Hope — have developed a more precise method that may help determine when it is best to surgically remove of pancreatic cancer tumors.

Released: 7-Apr-2023 2:50 PM EDT
Efficacy, safety of anakinra plus standard of care for patients with severe COVID-19
JAMA - Journal of the American Medical Association

In this randomized clinical trial, anakinra did not prevent the need for mechanical ventilation or reduce mortality risk compared with standard of care alone among hospitalized patients with severe COVID-19 pneumonia. Future research should assess anakinra in patients with less severe pneumonia.

Released: 6-Apr-2023 7:30 PM EDT
UM School of Medicine Researchers Chart Path Forward on Developing mRNA Vaccines for Infections Beyond COVID-19
University of Maryland School of Medicine

After helping to develop and test new mRNA technologies for COVID-19 vaccines, University of Maryland School of Medicine (UMSOM) researchers and scientists are turning their attention to utilizing this innovative technology to ward off other infectious diseases like malaria and influenza.

Newswise: Huntsman Cancer Institute March Research Highlights
Released: 6-Apr-2023 10:05 AM EDT
Huntsman Cancer Institute March Research Highlights
Huntsman Cancer Institute at the University of Utah

Read about cutting-edge cancer research centered around elephant genes, a new clinical trial, and grants to study vaccination hesitance in the Mountain West as well as chronic lymphocytic leukemia.

Released: 5-Apr-2023 7:50 PM EDT
Can phototherapy improve cognitive function in patients with dementia?
Wiley

In an analysis of published clinical trials, investigators found that phototherapy—or exposure to sessions of bright light—may be a promising non-pharmacological intervention for lessening symptoms of dementia.

Released: 4-Apr-2023 1:30 PM EDT
Hackensack University Medical Center Becomes Only Hospital in New Jersey to Offer Transcarotid Artery Revascularization (TCAR) Clinical Trial
Hackensack Meridian Health

Hackensack University Medical Center is the only site in New Jersey that is participating in the ROADSTER 3 clinical trial to assess real-world outcomes for patients with carotid artery disease who have an average surgical risk and undergo a minimally invasive surgical procedure called transcarotid artery revascularization (TCAR).

Released: 4-Apr-2023 1:25 PM EDT
Evidence-based consensus guidelines on patient selection and trial stimulation for spinal cord stimulation therapy for chronic non-cancer pain
McMaster University

Spinal cord stimulation (SCS) has demonstrated effectiveness for neuropathic pain. Unfortunately, some patients report inadequate long-term pain relief. Patient selection is emphasized for this therapy; however, the prognostic capabilities and deployment strategies of existing selection techniques, including an SCS trial, have been questioned.

Newswise: NANT Pediatric Cancer Consortium Spearheads Research That Identifies Targeted Therapy for High-Risk Neuroblastoma
Released: 4-Apr-2023 10:20 AM EDT
NANT Pediatric Cancer Consortium Spearheads Research That Identifies Targeted Therapy for High-Risk Neuroblastoma
Children's Hospital Los Angeles

The NANT pediatric cancer consortium at Children’s Hospital Los Angeles has published results of a phase 1 trial for high-risk neuroblastoma.

Newswise: Researchers Announce Findings from Landmark Clinical Trial for Pediatric Crohn’s Disease
Released: 3-Apr-2023 5:15 PM EDT
Researchers Announce Findings from Landmark Clinical Trial for Pediatric Crohn’s Disease
University of North Carolina Health Care System

A significant clinical trial under the direction of Michael Kappelman, MD, MPH, professor of pediatrics at UNC School of Medicine, found that patients receiving the tumor necrosis factor inhibitor adalimumab combined with a low dose of methotrexate, a second immunosuppressant, did better than those treated with infliximab alone. Patients who received infliximab, another tumor necrosis factor inhibitor, had similar outcomes with or without methotrexate.

31-Mar-2023 11:00 AM EDT
Researchers Show Lorlatinib is Safe and Effective for Patients with ALK-Driven Relapsed/Refractory High-Risk Neuroblastoma
Children's Hospital of Philadelphia

In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children’s Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma.



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