Newswise Feature Channel: Bone Health

Study Reveals Link Between Abdominal CT Use and Sarcopenia Diagnosis Among Older Adults

Harvey L. Neiman Health Policy Institute — Thu, 17 Apr 2025 09:00:00 EST

A new Harvey L. Neiman Health Policy Institute study found evidence that a new diagnosis of sarcopenia, a potentially reversible disease with low muscle mass and strength, often coincides with an abdominal CT study. Increasing opportunistic evaluation of abdominal CT scans could facilitate diagnosis of sarcopenia and ultimately improve patient care.

New Drug Targets Bone Disease by Blocking the Wnt Signaling Pathway

Chinese Academy of Sciences — Wed, 16 Apr 2025 08:10:47 EST

Sclerosteosis is a rare genetic disorder that causes excessive bone growth, leading to life-altering complications, including hearing loss and facial paralysis. In a promising new breakthrough, researchers have identified a drug called LGK974, which targets the Wnt signaling pathway by inhibiting the enzyme Porcupine.

Largest Genome-Wide Association Study Uncovers New Drug Targets and Potential Therapies for Osteoarthritis

University of Maryland School of Medicine — Tue, 15 Apr 2025 18:10:19 EST

Largest Genome-Wide Association Study Uncovers New Drug Targets and Potential Therapies for Osteoarthritis

Unlocking Faster Orthodontic Treatments: The Role of ATF6 in Bone Remodeling

Chinese Academy of Sciences — Tue, 15 Apr 2025 04:00:08 EST

Orthodontic treatments often take years, but a breakthrough discovery could drastically shorten this period. Researchers have uncovered that ATF6, a protein activated in macrophages during corticotomy, accelerates tooth movement by promoting inflammation and boosting the production of TNFα, a key factor in bone remodeling. This finding paves the way for faster, more efficient orthodontic procedures, minimizing both treatment time and patient discomfort. The study highlights the potential for non-invasive therapies that could reshape the future of orthodontic care.

Immune Cell 'Messengers' Could Save Crumbling Bones - New Hope for Joint Pain Sufferers

Chinese Academy of Sciences — Mon, 14 Apr 2025 10:40:56 EST

A recent study has uncovered a potential breakthrough in treating osteonecrosis of the femoral head (ONFH), a debilitating bone disease that causes severe pain and joint collapse. Researchers have discovered that exosomes derived from M2 macrophages-derived exosomes (M2-Exos) can significantly improve bone regeneration by modulating neutrophil extracellular traps (NETs) and endothelial cell function. These tiny vesicles, packed with miR-93-5p, were shown to reduce harmful NETs formation and enhance blood vessel growth, offering a novel therapeutic approach. This discovery highlights the potential of M2-Exos to address the root causes of ONFH, paving the way for non-invasive treatments that could prevent bone deterioration and improve patient outcomes.

Penn Medicine Breaks Ground on Innovative Outpatient Center in Montgomery County

Perelman School of Medicine at the University of Pennsylvania — Fri, 11 Apr 2025 18:00:59 EST

Penn Medicine leaders and regional community representatives broke ground today on a four-story, 162,000-square-foot multispecialty outpatient facility that will expand options for patients to receive advanced care in Montgomery and Bucks counties.

Alternative to Hip Replacement Keeps Aging Athletes in the Game

Washington University in St. Louis — Fri, 11 Apr 2025 10:35:37 EST

Robert Barrack, MD, the Charles F. and Joanne Knight Professor of Orthopaedic Surgery at WashU Medicine, led a long-term study that showed that patients who received a Birmingham hip resurfacing procedure maintained a higher level of athletic activity years after their surgery than those who received a total hip replacement.

New Breakthrough Combats Lenalidomide Resistance in Multiple Myeloma

National University of Singapore (NUS) — Wed, 09 Apr 2025 21:40:49 EST

A new study conducted by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has uncovered a key mechanism behind lenalidomide resistance in multiple myeloma (MM), offering new insights into potential strategies for improving treatment outcomes and overcoming drug resistance.

Two Paths to Healing: Organoids Reveal Sex-Specific Bone Regeneration Mechanisms

Chinese Academy of Sciences — Wed, 09 Apr 2025 06:45:33 EST

Recent findings in bone regeneration research, highlights the significant impact of biological sex and donor variability on healing processes, offering promising new approaches to personalized medicine. By modeling cartilage-to-bone transition with innovative callus organoids, scientists discovered two distinct pathways--hypertrophic cartilage and fibrocartilage--driven by early progenitor cell activation.

Casey G. Batten, MD, Named Chief Medical Officer for LA28 Olympic and Paralympic Games

Cedars-Sinai — Tue, 08 Apr 2025 21:20:21 EST

Cedars-Sinai sports medicine specialist Casey G. Batten, MD, has been named chief medical officer for the LA28 Olympic and Paralympic Games in Los Angeles.

Researchers' Study Show Advancements in GP38 Contributions to CCHFV and Monoclonal Antibody Therapies

U.S. Army Medical Research Institute of Infectious Diseases — Tue, 08 Apr 2025 21:15:15 EST

A recent study published in Science Translational Medicine involving scientists from the U.S. Army Medical Research Institute of Infectious Diseases in collaboration with scientists from the Albert Einstein College of Medicine and the University of California-Berkeley have advanced discoveries surrounding the viral glycoprotein GP38 expressed by the Crimean-Congo hemorrhagic fever virus (CCHFV).

Ventris Medical Receives Additional FDA Clearance for Backpack(r) Bone Graft in the Intervertebral Disc Space

Ventris Medical — Tue, 08 Apr 2025 07:05:46 EST

Ventris Medical, a privately held orthobiologics and tissue regeneration company, today announced that the United States Food and Drug Administration has granted 510(k) clearance for Backpack(r) (Porous Biologic Scaffold, K250556) for use in the Intervertebral Disc Space.

Experts Debate Management of Patient with Decreased Bone Density

American College of Physicians (ACP) — Mon, 07 Apr 2025 17:00:00 EST

In a new Annals "Beyond the Guidelines" feature, two bone endocrinologists debate how to manage a 65-year-old female patient with both osteopenia and osteoporosis on bone densitometry in the context of the American College of Physicians updated guidance on the pharmacologic treatment of osteoporosis.

Non-radiologist Ordering Providers Interpret 43.6% of Office-based Imaging

Harvey L. Neiman Health Policy Institute — Wed, 02 Apr 2025 09:00:00 EST

A new Neiman Health Policy Institute study found that 43.6% of office-based imaging studies were interpreted by the ordering provider, with 58.5% interpreted within the ordering provider's practice. Self-interpretation rates varied by specialty and imaging modality.

Experimental Blood Test Shown to Accurately Indicate Severity and Predict Potential Recovery from Spinal Cord Injury

Johns Hopkins Medicine — Mon, 31 Mar 2025 11:00:37 EST

By analyzing DNA and proteins in the blood of people with and without acute spinal cord injuries (SCIs), researchers at the Johns Hopkins University School of Medicine have developed a novel blood test that has the potential to rapidly predict severity and likelihood of sensory and motor recovery within six months in a cost-effective manner.

Enhanced Recovery Pathways Slash Opioid Prescriptions in Iowa Hospitals

The Rothman Orthopaedic Institute Foundation for Opioid Research and Education — Mon, 31 Mar 2025 09:05:48 EST

recent study conducted across nine Iowa hospitals has shown promising results in reducing postoperative opioid prescriptions by implementing Enhanced Recovery After Surgery (ERAS) pathways. The study, led by researchers from the Rothman Opioid Foundation, Goldfinch Health, and Drexel University College of Medicine, examined the impact of ERAS protocols on opioid prescribing to patients undergoing arthroplasty (joint replacement surgery) and arthroscopy (a minimally invasive procedure to diagnose and treat joint issues). Arthroplasty involves replacing damaged joints with prosthetic implants to relieve pain and restore function, whereas arthroscopy utilizes a small camera to examine and repair joint damage through small incisions.

New Method Creates 854x More Mitochondria, Offering Hope for Cartilage Regeneration

Chinese Academy of Sciences — Mon, 31 Mar 2025 06:10:32 EST

Scientists have unveiled a revolutionary method for mass-producing high-quality human mitochondria, potentially transforming treatments for degenerative diseases. By refining stem cell culture conditions, researchers achieved an extraordinary 854-fold increase in mitochondrial production while significantly enhancing energy output.

Meniscus Injuries May Soon Be Treated by Customizable Hydrogel

Perelman School of Medicine at the University of Pennsylvania — Fri, 28 Mar 2025 19:00:59 EST

A new 3D printed customizable hydrogel performed well in preclinical trials with several different types of meniscal tears

Endocrine Society Statement on HHS Restructuring, Mass Firings, and Scientific Review

Endocrine Society — Fri, 28 Mar 2025 18:15:20 EST

A major reorganization of the U.S. Department of Health and Human Services (HHS)--including massive cuts to the federal workforce--threatens scientific progress that drives our economy and improves the public's health.

CD47 Protein Crucial for Bone Fracture Healing, Study Reveals

Chinese Academy of Sciences — Wed, 26 Mar 2025 22:10:55 EST

A new discovery has shed new light on the crucial role of the CD47 protein in bone fracture healing. Scientists have identified CD47 as an essential regulator of mesenchymal progenitor cell (MSC) proliferation--cells critical for bone repair. Without CD47, bone healing was significantly delayed, with reduced callus formation and diminished bone volume in both normal and ischemic fracture models. These findings suggest that targeting CD47 could pave the way for novel therapeutic strategies to enhance fracture recovery, particularly in cases where blood supply is compromised.