Newswise Feature Channel: Clinical Trials

Topical Mupirocin Lowers Lupus Inflammation

Michigan Medicine - University of Michigan — Wed, 29 Jan 2025 21:20:28 EST

Systemic lupus erythematosus, more commonly known as lupus, has a variety of symptoms and room for improvement when it comes to treatment.Cutaneous lupus erythematosus is a common manifestation of systemic lupus erythematosus.The condition is characterized by rashes on various parts of the body including the face and scalp, hair loss and scarring of the skin.

Lantheus to Acquire Evergreen Theragnostics for Upfront Payment of $250 Million to Drive Strategic Evolution into Fully Integrated Radiopharmaceutical Leader

Evergreen Theragnostics, Inc. — Tue, 28 Jan 2025 07:10:05 EST

Lantheus Holdings, Inc. ("Lantheus" or the "Company") (NASDAQ: LNTH), the leading radiopharmaceutical-focused company committed to enabling clinicians to Find, Fight and Follow disease to deliver better patient outcomes, today announced a definitive agreement to acquire Evergreen Theragnostics, Inc. ("Evergreen"), in an all-cash transaction consisting of an upfront payment of $250 million and up to an additional $752.5 million in potential milestone payments.

The Miami Project to Cure Paralysis at the University of Miami Miller School of Medicine Selected as a U.S. Site for Neuralink Clinical Trial

University of Miami Health System, Miller School of Medicine — Mon, 27 Jan 2025 18:45:02 EST

The Miami Project to Cure Paralysis and the Department of Neurological Surgery at the University of Miami (UM) Miller School of Medicine have been selected to become the second U.S.-based site for Neuralink's PRIME Study, an investigational medical device clinical trial for Neuralink's ground-breaking brain-computer interface.

New Study Examines if 'Inoperable' Pancreatic Tumors Can Be Safely Removed

Keck Medicine of USC — Mon, 27 Jan 2025 15:50:11 EST

A clinical trial from Keck Medicine of USC aims to provide a surgical solution for patients with a form of advanced pancreatic cancer previously considered inoperable.

Loyola Named to Becker's 2024 List of 100 Great Neuro and Spine Programs

Loyola Medicine — Fri, 24 Jan 2025 18:05:28 EST

Loyola Medicine has been named to Becker's Hospital Review's 2024 list of 100 Great Neuro and Spine Programs.

Two New Artificial Intelligence Models Seek to Make MRI More Accurate, Reliable

University of North Carolina School of Medicine — Thu, 23 Jan 2025 20:25:06 EST

Two new models, developed by researchers in the lab of Li Wang, PhD, associate professor of radiology in the UNC School of Medicine, can produce more accurate and reliable analysis of brain structures, which is critical for early detection, medical diagnosis, and neurological research.

Metronomic Chemotherapy: A Promising Approach for Pediatric Neuroblastoma

Chinese Academy of Sciences — Thu, 23 Jan 2025 09:05:00 EST

Metronomic chemotherapy (MC) is emerging as a groundbreaking treatment for pediatric neuroblastoma, offering a more accessible and manageable option for children with high-risk and relapsed/refractory forms of the disease. This innovative approach could revolutionize care, particularly in low-resource settings where traditional treatments are often out of reach. A recent comprehensive review explores the evolution, clinical applications, and prospects of MC, shedding light on its potential to improve outcomes while reducing toxicity.

mRNA-Activated Blood Clots Could Cushion the Blow of Osteoarthritis

University of Wisconsin-Madison — Wed, 22 Jan 2025 20:45:58 EST

University of Wisconsin-Madison researchers have developed a promising technique for treating osteoarthritis using therapeutic blood clots activated by messenger RNA.

Clinical Trial to Study New Use for CAR T-cell Therapy: Treating Autoimmune Diseases

University of Chicago Medical Center — Tue, 21 Jan 2025 19:45:52 EST

The University of Chicago Medicine has launched a Phase 2 clinical trial to study how CAR T-cell therapy could be used to treat three autoimmune diseases.

Stuart Therapeutics Announces Completion of Phase 3 Dry Eye Disease Clinical Trial

Stuart Therapeutics — Tue, 21 Jan 2025 18:45:04 EST

Stuart Therapeutics, Inc. (Stuart), a clinical-stage drug platform company developing novel therapies for ophthalmic diseases, today announced last patient last visit in the phase III study of its lead therapeutic candidate ST-100 (vezocolmitide) for treatment of Dry Eye Disease. Topline data results are expected in February 2025.

Neurological Applications of Focused Ultrasound: An Introduction and Update on Clinical and Research Trends

Egyptian Journal of Radiology and Nuclear Medicine — Tue, 21 Jan 2025 05:35:41 EST

Houston Methodist Researchers Identify Key Protein to Potentially Halt Autoimmune Diseases and Allergies

Houston Methodist — Mon, 20 Jan 2025 19:00:15 EST

Houston Methodist researchers have identified a key protein as a potential therapeutic target for stopping the body's immune system from mistakenly attacking itself, offering new hope for treating autoimmune diseases and allergies.

Unique Characteristics of a Rare Liver Cancer Identified as Clinical Trial of New Treatment Begins

Rockefeller University — Fri, 17 Jan 2025 19:00:22 EST

Long classified as a subset of common liver cancer, FLC should be considered its own unique disease. Now researchers are testing a combination drug therapy that targets FLC tumors.

Phase 2 LITESPARK-003 Results Suggest Continued Study of Novel First-Line Combo for Advanced Kidney Cancer

Dana-Farber Cancer Institute — Fri, 17 Jan 2025 09:00:59 EST

Current first-line treatment for advanced clear-cell renal cell carcinoma includes anti-PD1 or anti-PD-L1 immunotherapy in combination with a CTLA-4 inhibitor or a VEGF tyrosine kinase inhibitor such as cabozantanib. These options have improved outcomes in patients, however not all patients respond, and some responses do not last. This study's results suggest that further investigation of this novel combination as first-line therapy option is warranted.

Appendectomy or Antibiotics: Which Is a Better Choice for Children's Appendicitis?

University of Manitoba — Fri, 17 Jan 2025 08:55:45 EST

In pediatric medicine, there's growing interest in treating kids and teens who have uncomplicated appendicitis with intravenous (IV) antibiotics instead of surgery.

The Staying Power of Bifocal Contact Lens Benefits in Young Kids

Ohio State University — Thu, 16 Jan 2025 19:05:22 EST

Young nearsighted kids who wear bifocal contact lenses that slow uncoordinated eye growth do not lose the benefits of the treatment once they stop wearing the lenses, new research shows.

A Common Antihistamine Shows Promise in Treating Liver Complications of a Rare Disease Complication

Rutgers University-New Brunswick — Tue, 14 Jan 2025 17:15:35 EST

Rutgers Health researchers find that allergy medicine could help patients with a rare genetic disease avoid liver transplants.

Dr. Jennifer Jao Named Co-Chair of International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) Network

Ann and Robert H. Lurie Children's Hospital of Chicago — Mon, 13 Jan 2025 18:45:44 EST

Dr. Jao has been involved with the Network as Protocol Co-Chair of IMPAACT P1115, which promising findings last year that children born with HIV who started treatment promptly after birth surpassed a year of remission after pausing antiretroviral therapy.

Dr. Mitchell Posner named Chief Clinical Officer for the University of Chicago Medicine Comprehensive Cancer Center and cancer services

University of Chicago Medical Center — Mon, 13 Jan 2025 16:35:03 EST

Mitchell C. Posner, MD, has been appointed Chief Clinical Officer of the UChicago Medicine Comprehensive Cancer Center and the health system's Cancer Service Line, overseeing day-to-day clinical operations of the cancer services across the health system as well as the new Cancer Pavilion.

KU-Led Multicenter Trial to Address Food Insecurity and Malnutrition in Cancer Patients

University of Kansas Cancer Center — Mon, 13 Jan 2025 14:55:24 EST

Researchers are leading a multicenter trial, funded by a five-year, nearly $4 million grant awarded last fall by the National Institutes of Health, to tackle food insecurity in people with blood cancers who are receiving transplant or cellular therapy.