The new study, led by researchers in the Saphire Lab at LJI, reveals the inner workings of the Ebola virus nucleocapsid. LA JOLLA, CA—At this moment, the world has few tools to combat deadly filoviruses, such as Ebola and Marburg viruses. The only approved vaccine and antibody treatments protect against just one filovirus species.
What if a drug could help you live a longer, healthier life? Scientists at the University of Connecticut are working on it. In a new study in Cell Metabolism, researchers described how to target specific cells to extend the lifespan and improve the health of mice late in life.
University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, has announced the formation of a new Department of Pharmacology, Physiology and Drug Development, which merges the Department of Physiology and Department of Pharmacology. This new Department aligns the basic science research efforts of both entities with a strong emphasis on the development of new drug therapies.
A Texas A&M AgriLife Research team is working to find crop varieties, starting with sorghum, that will minimize that escaped nitrogen, thus reducing input costs for farmers and greenhouse gas emissions into the atmosphere.
The LJI team uncovered important similarities between H5N1 and these common viruses, which allowed them to predict that many people already have "cross-reactive" T cells that are ready to target H5N1—should it ever mutate to cause widespread disease in humans.
Rutgers Health researchers will enroll primary or secondary progressive multiple sclerosis (p-MS) patients to see if an engineered immune cell therapy can halt the progression of the autoimmune disease.
During every moment of any living organism’s life, enzymes are at work. These crucial proteins support life through most biological processes, including metabolism, movement, respiration, and digestion. “Enzymes’ effects in cells are part of normal physiology,” said Kathleen Mulvaney, assistant professor at Virginia Tech’s Fralin Biomedical Research Institute.
The antibody-drug conjugate (ADC) puxitatug samrotecan (AZD8205) demonstrated a manageable safety profile consistent with similar ADCs and initial efficacy in heavily pretreated patients with advanced or metastatic solid tumors, according to interim data shared today at the 2024 European Society for Medical Oncology (ESMO) Congress by researchers from The University of Texas MD Anderson Cancer Center.
A new USDA-supported project based at Iowa State University will create an encyclopedia of livestock species' genetic regulatory regions, a DNA netherworld that could be useful in breeding for improved animal efficiency and health.
A recent study highlights the pivotal role of alternative splicing in controlling plant secondary metabolism, which is crucial for producing bioactive compounds with significant medicinal and industrial value.
The Cedars-Sinai Board of Governors Regenerative Medicine Institute is creating a resource laboratory to help advance stem cell-based technologies throughout Cedars-Sinai and across California.
Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients. This discovery has fueled new strategies that incorporate antibodies and gene editing to improve the outcome of this breakthrough treatment for patients.
A pivotal study has decoded the genetic basis of olive oil production, revealing a key regulatory mechanism that shapes oil biosynthesis. By mapping the olive tree’s genome and metabolic pathways, researchers have identified how MYC2, a critical transcription factor, orchestrates the balance between fatty acid and flavonoid synthesis.
A recent study sheds light on Panax notoginseng, also known as Sanchi, by delving into its phytochemical profile and pharmacological potential. The research provides an in-depth review of the biosynthesis and regulation of ginsenosides, the herb's primary bioactive compounds known for their therapeutic effects.
Scientists have decoded the genetic blueprint of Atractylodes lancea, a prized herb in traditional Chinese medicine. Through comprehensive genome resequencing, the study unveils how natural variations drive the plant's evolution and metabolic adaptations, particularly affecting the production of key medicinal compounds.
Temple University’s Sbarro Institute for Cancer Research and Molecular Medicine has benefited from the support of Pennsylvania State Sen. Ryan Aument since he took office in 2014.
Researchers in ACS Central Science report a sugar-like polymer that traps heavy metals within insoluble clumps for easy removal. In proof-of-concept tests, the polymer removed ionic cadmium and lead from river water spiked with these persistent contaminants.
A recent study discovered that applying 5-Azacytidine, a DNA methylation inhibitor, significantly reduces tomato susceptibility to gray mold, a common postharvest fungal disease. This epigenetic strategy enhances the fruit's natural defense system, offering a sustainable and innovative method to boost crop resistance without genetic modification.
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