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Feature Channels: Clinical Trials

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Newswise: AACR: Novel immunotherapies show promise for patients with kidney cancer and for solid organ transplant recipients with skin cancer
4-Apr-2024 3:00 PM EDT
AACR: Novel immunotherapies show promise for patients with kidney cancer and for solid organ transplant recipients with skin cancer
University of Texas MD Anderson Cancer Center

Researchers from The University of Texas MD Anderson Cancer Center presented encouraging findings today from two clinical trials in a plenary session highlighting advances in novel immunotherapy approaches at the American Association for Cancer Research (AACR) Annual Meeting 2024.

   
3-Apr-2024 10:05 AM EDT
AACR: Preliminary study finds immunotherapy combination before surgery improves outcomes for patients with pancreatic cancer
University of California, Los Angeles (UCLA), Health Sciences

A pilot study led by UCLA Health Jonsson Comprehensive Cancer Center investigators suggests that for people with borderline resectable pancreatic cancer, administrating an immunotherapy drug in combination with chemotherapy before surgery is safe and may improve long-term outcomes.

Released: 3-Apr-2024 6:05 PM EDT
Tip Sheet: Weight loss drugs and cancer prevention, Fred Hutch at AACR, lymphedema Q&A — and new vice president and chief nursing officer
Fred Hutchinson Cancer Center

SEATTLE — April 3, 2024 — Below are summaries of recent Fred Hutchinson Cancer Center research findings, patient stories and other news. If you’re covering the American Association for Cancer Research (AACR) Annual Meeting, please see our list of and contact to set up interviews.

Newswise: Wilmer Eye Institute Awarded More Than $20 Million for Clinical Trial Investigating Genetic Eye Condition
Released: 3-Apr-2024 10:00 AM EDT
Wilmer Eye Institute Awarded More Than $20 Million for Clinical Trial Investigating Genetic Eye Condition
Johns Hopkins Medicine

The Wilmer Eye Institute, Johns Hopkins Medicine has received two awards totaling more than $20 million from the National Eye Institute at the National Institutes of Health, both of which will be used for a six-year clinical trial investigating a potential treatment for the most common inherited retinal disease, retinitis pigmentosa.

Newswise: 1920_cedars-sinai-plaza-level.jpg?10000
Released: 3-Apr-2024 1:05 AM EDT
Curtis L. Cetrulo, Jr., MD, Selected as Lyon Family Chair in Plastic Surgery
Cedars-Sinai

Curtis L. Cetrulo Jr., MD, vice chair of Research in the Department of Surgery and director of the Division of Plastic Surgery, has been selected as the General William and Willa Dean Lyon Family Chair in Reconstructive and Plastic Surgery.

Released: 2-Apr-2024 4:00 PM EDT
One in five people with cancer participate in medical research studies
Fred Hutchinson Cancer Center

Researchers from Fred Hutchinson Cancer Center, the American Cancer Society Cancer Action Network and peer institutions released new findings in the Journal of Clinical Oncology showing that when all types of cancer research studies are considered, at least one in five people with cancer in the U.S., or 21.9%, participate in some form of clinical research.

Not for public release

This news release is embargoed until 1-Apr-2024 5:05 PM EDT Released to reporters: 1-Apr-2024 5:05 PM EDT

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Newswise:Video Embedded yale-cancer-center-experts-scientists-to-share-vision-and-research-at-leading-conference
VIDEO
Released: 1-Apr-2024 2:05 PM EDT
Yale Cancer Center Experts, Scientists to Share Vision and Research at Leading Conference
Yale Cancer Center/Smilow Cancer Hospital

The five-day session (April 5-10), themed as “Inspiring Science. Fueling Progress. Revolutionizing Care,” will include new findings from Yale Cancer Center researchers.

Released: 1-Apr-2024 10:05 AM EDT
UChicago Medicine: NCI renews Cancer Center's premier 'Comprehensive' designation amid 50th anniversary celebration
University of Chicago Medical Center

A 'Comprehensive Cancer Center' is the top U.S. designation for cancer research and treatment facilities recognized by high-quality research that leads to major shifts in cancer care.

Newswise: Study explores the future of at-home cancer treatment
Released: 28-Mar-2024 12:00 PM EDT
Study explores the future of at-home cancer treatment
Keck Medicine of USC

A clinical trial from Keck Medicine of USC will test the feasibility of treating non-small cell lung cancer with immunotherapy provided at home.

Newswise: Combining Epigenetic Cancer Medications May Have Benefit for Colorectal Cancers and Other Tumor Types
27-Mar-2024 1:30 PM EDT
Combining Epigenetic Cancer Medications May Have Benefit for Colorectal Cancers and Other Tumor Types
Van Andel Institute

A pair of medications that make malignant cells act as if they have a virus could hold new promise for treating colorectal cancers and other solid tumors, reports a study published today in Science Advances.

Newswise: Gene Therapy Offers Hope for Giant Axonal Neuropathy Patients
Released: 27-Mar-2024 12:05 PM EDT
Gene Therapy Offers Hope for Giant Axonal Neuropathy Patients
UT Southwestern Medical Center

A gene therapy developed by researchers at UT Southwestern Medical Center for a rare disease called giant axonal neuropathy (GAN) was well tolerated in pediatric patients and showed clear benefits, a new study reports. Findings from the phase one clinical trial, published in the New England Journal of Medicine, could offer hope for patients with this rare condition and a host of other neurological diseases.

Released: 27-Mar-2024 10:05 AM EDT
UCI Health celebrates transformational acquisition of four community hospitals
University of California, Irvine

UCI Health, the clinical enterprise of the University of California, Irvine, has completed the acquisition of four hospitals and associated outpatient locations from Tenet Healthcare Corporation.

Newswise: Empowering Minority Cancer Patients: Tips for Advocacy and Support
Released: 27-Mar-2024 9:05 AM EDT
Empowering Minority Cancer Patients: Tips for Advocacy and Support
Rutgers Cancer Institute of New Jersey

Mariam F. Eskander, MD, MPH, surgical oncologist in the Gastrointestinal Oncology Program at Rutgers Institute of New Jersey, offers insight and tips for minority individuals navigating a cancer diagnosis and how we can all work together to mitigate cancer disparities.

Newswise: 10 Facts about Head & Neck Cancers
Released: 27-Mar-2024 9:05 AM EDT
10 Facts about Head & Neck Cancers
Rutgers Cancer Institute of New Jersey

Head and neck cancer is the term used to describe a number of different malignant tumors that develop in or around the throat, larynx, nose, sinuses and mouth.

Released: 25-Mar-2024 12:05 PM EDT
Friend or foe: A closer look at the role of health care algorithms in racial and ethnic disparities
Perelman School of Medicine at the University of Pennsylvania

For years, it was harder for Black patients to secure a coveted spot on the national kidney transplant waitlist because a clinical algorithm was making Black patients appear healthier than they were.

Newswise: Inflammation-Reducing Drug Shows No Benefit for Dry Age-Related Macular Degeneration in Nih Trial
Released: 21-Mar-2024 11:30 AM EDT
Inflammation-Reducing Drug Shows No Benefit for Dry Age-Related Macular Degeneration in Nih Trial
NIH, National Eye Institute (NEI)

The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic atrophy in people with dry age-related macular degeneration (AMD), according to a phase II clinical study at the National Eye Institute (NEI), part of the National Institutes of Health.

Released: 21-Mar-2024 7:05 AM EDT
ScienceMedia Welcomes Visionary Leaders to Advisory Board, Paving the Way for a New Era of Innovation
ScienceMedia

ScienceMedia, a global SaaS provider redefining the landscape of clinical mastery in the biotech and pharma industries, announces the formation of its inaugural advisory board.

Released: 20-Mar-2024 5:05 PM EDT
Adding ribociclib to hormone therapy reduces the risk of breast cancer recurrence
University of California, Los Angeles (UCLA), Health Sciences

A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators.

Released: 19-Mar-2024 11:05 AM EDT
ATS 2024 Conference Program is Live! Register Now for Scientific Sessions in Pulmonary, Critical Care and Sleep Medicine
American Thoracic Society (ATS)

The ATS 2024 International Conference Program is now live! Get ready for a series of dynamic scientific programming with presentations covering AI in thoracic medicine, the basic sciences, research breakthroughs and clinical treatment, as well as spotlighting the next generation of innovators in pulmonary, critical care and sleep medicine.

Released: 19-Mar-2024 10:05 AM EDT
Chop Researchers Find Branched Chain Amino Acid Supplementation May Aid in Concussion Recovery
Children's Hospital of Philadelphia

In the first clinical trial of a targeted pharmacologic therapeutic for mild traumatic brain injury in pediatric patients, scientists have found preliminary evidence that adolescents and young adults with concussion who take a specific formulation of branched chain amino acid (BCAA) supplements after injury experience faster symptom reduction and return to physical activity.

Newswise: Role in mitochondrial metabolism paints more complete picture of MCL-1 function
Released: 18-Mar-2024 3:05 PM EDT
Role in mitochondrial metabolism paints more complete picture of MCL-1 function
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital have uncovered a metabolic role for cell-survival protein MCL-1, potentially explaining previous clinical trial setbacks.

Released: 18-Mar-2024 3:05 PM EDT
Memorial Sloan Kettering Awarded Prestigious NCI Grant to Further Advance CAR T Cell Treatments for Solid Tumors
Memorial Sloan Kettering Cancer Center

A team at Memorial Sloan Kettering Cancer Center (MSK) led by thoracic surgeon Prasad Adusumilli, MD, has been awarded a distinguished UG3/UH3 grant from the National Cancer Institute (NCI) to advance research and testing of chimeric antigen receptor (CAR) T cell therapy for solid tumors.

Newswise: Cleveland Clinic-Led Research Concludes Video Laryngoscopy is Most Effective Method for Intubating Patients Undergoing Surgical Procedures
Released: 18-Mar-2024 1:25 PM EDT
Cleveland Clinic-Led Research Concludes Video Laryngoscopy is Most Effective Method for Intubating Patients Undergoing Surgical Procedures
Cleveland Clinic

New Cleveland Clinic-led research provides evidence that video laryngoscopy significantly decreased the number of attempts needed to achieve intubation in adult surgical patients who required single-lumen endotracheal intubation for general anesthesia, compared with direct laryngoscopy. The research was published today in JAMA.

Released: 18-Mar-2024 9:00 AM EDT
St. Baldrick’s Foundation Awards $50,000 Grant to Expand Pediatric Cancer Clinical Trials at K. Hovnanian Children’s Hospital
Hackensack Meridian Health

St. Baldrick’s Foundation Awards $50,000 Grant to Expand Pediatric Cancer Clinical Trials at K. Hovnanian Children’s Hospital

Released: 14-Mar-2024 5:05 PM EDT
UChicago Medicine helps bring first-of-its-kind drug for metabolic liver disease to the clinic
University of Chicago Medical Center

Resmetirom (Rezdiffra) is the first drug approved for treating MASH, an advanced form of fatty liver disease. UChicago Medicine experts contributed to a recent clinical trial and will begin incorporating the drug into liver disease treatment regimens for eligible patients.

Released: 14-Mar-2024 3:40 PM EDT
Positive Results from Diabetic Foot Ulcer Clinical Trial Show Dramatic Healing Rate within 12 Weeks or Less Using Novel Omeza® Platform and Offloading
Omeza LLC

Omeza®, a regenerative skincare company that develops marine-based therapies for the treatment of chronic wounds, today presented positive interim data from a diabetic foot ulcer (DFU) clinical trial showing that Omeza® OCM™ plus offloading of weight on the affected foot achieved a 91 percent area reduction (PAR) rate in DFUs within twelve weeks, and a 63 percent PAR within four weeks.

Newswise: New Study Examines if ‘Inoperable’ Pancreatic Tumors Can Be Safely Removed
Released: 14-Mar-2024 12:00 PM EDT
New Study Examines if ‘Inoperable’ Pancreatic Tumors Can Be Safely Removed
Keck Medicine of USC

A clinical trial from Keck Medicine of USC aims to provide a surgical solution for patients with a form of advanced pancreatic cancer previously considered inoperable.

Newswise: Glaucoma Research Foundation Announces $2.5 Million in Grants to Cure Glaucoma
Released: 14-Mar-2024 7:00 AM EDT
Glaucoma Research Foundation Announces $2.5 Million in Grants to Cure Glaucoma
Glaucoma Research Foundation

“This is the largest annual research budget in our 46-year history,” said Thomas M. Brunner, GRF President and CEO.

Released: 13-Mar-2024 10:05 AM EDT
Novel Oral Hormone Therapy Shows Promising Results for Prostate Cancer Treatment with Radiation Therapy
University Hospitals Cleveland Medical Center

A high impact study led by Daniel Spratt, MD, Vincent K. Smith Chair in Radiation Oncology at University Hospitals Seidman Cancer Center demonstrates the safety and efficacy of a novel oral hormone therapy, relugolix, in conjunction with radiation therapy for treating men with localized and advanced prostate cancer. This work is published in JAMA Oncology.

Newswise: Phase 3 CELLEBRATE Trial Testing Regenerative Stem Cell-Based Therapy to Improve Urinary Control for Women
Released: 11-Mar-2024 2:05 PM EDT
Phase 3 CELLEBRATE Trial Testing Regenerative Stem Cell-Based Therapy to Improve Urinary Control for Women
Vanderbilt University Medical Center

The Phase 3 CELLEBRATE trial to test a regenerative stem cell-based therapy in treating patients with stress urinary incontinence is continuing to recruit additional subjects after changing its study protocol to include only patients who have already tried surgery.

9-Mar-2024 9:05 AM EST
BIDMC-led trial leads to FDA approval of coronary drug-coated balloons
Beth Israel Deaconess Medical Center

In the largest randomized clinical trial and first of its kind to date in the United States, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) assessed the efficacy and safety of using a drug-coated balloon in patients undergoing coronary angioplasty.

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Released: 8-Mar-2024 10:05 AM EST
Cedars-Sinai Experts Studying Device for Controlling Treatment-Resistant Hypertension
Cedars-Sinai

The Smidt Heart Institute at Cedars-Sinai recently became one of four institutions in the U.S. and the first on the West Coast to use a new device aimed at lowering blood pressure in patients with difficult-to-treat hypertension.

Newswise: This Injectable Hydrogel Mitigates Damage to the Right Ventricle of the Heart
29-Feb-2024 7:00 AM EST
This Injectable Hydrogel Mitigates Damage to the Right Ventricle of the Heart
University of California San Diego

An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study published March 6 in Journals of the American College of Cardiology: Basic to Translational Science.  The study, by a research team from the University of California San Diego, Georgia Institute of Technology and Emory University, was conducted in rodents.

Released: 5-Mar-2024 5:05 PM EST
Tip Sheet: Colorectal cancer awareness resources, new initiative for rare cancers, immunotherapy for Merkel cell carcinoma — and Fred Hutch-led Cancer Screening Research Network launches
Fred Hutchinson Cancer Center

Below are summaries of recent Fred Hutchinson Cancer Center research findings and other news. March is Colorectal Cancer Awareness Month, contact our media team to set up interviews.

Newswise: UTEP Clinical Trial to Encourage Healthy Walking Habits
Released: 5-Mar-2024 5:05 PM EST
UTEP Clinical Trial to Encourage Healthy Walking Habits
University of Texas at El Paso

Health researchers at The University of Texas at El Paso are launching a clinical trial to improve walking in the El Paso community, thanks to a $4.4 million grant from the National Institutes of Health. The project will enroll local school district employees in 50K 4 Life, a program that challenges them to improve their health by walking at least 50,000 steps per week.

Released: 5-Mar-2024 9:05 AM EST
Developing New Approaches for Children With Cystic Fibrosis
Children's Hospital Los Angeles

Over the past decade, the advent of new medications has been a game changer for many children and adults with cystic fibrosis (CF). But while these therapies can significantly enhance lung function, they are not a cure—and not all patients are eligible for them. At Children’s Hospital Los Angeles, the Cystic Fibrosis Center is dedicated to improving the lives of all children with CF.

Released: 4-Mar-2024 8:05 AM EST
HIV Medication Can be Used Safely with Gender-Affirming Hormone Therapy
Thomas Jefferson University

New research shows HIV medications can be taken at the same time as hormone treatment without losing potency of either therapy.

Released: 1-Mar-2024 5:00 AM EST
Targeted drug shows promising ability in treating rare head and neck cancers
Michigan Medicine - University of Michigan

Experts at Rogel Cancer Center develop and study the impact of a new drug for salivary gland cancers

Released: 28-Feb-2024 10:05 PM EST
New study finds high-dose inhaled nitric oxide decreases the risk of death among critically ill Black patients with COVID-19
University of Alabama at Birmingham

In a first-of-its-kind study published in the American Journal of Respiratory and Critical Care Medicine, physician-scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine discovered that high-dose inhaled nitric oxide therapy may improve oxygenation and reduce the risk of mortality among critically ill Black patients with COVID-19.

Released: 28-Feb-2024 3:05 PM EST
How New Drug Approvals are Reshaping Treatment for Eosinophilic Esophagitis
University of North Carolina School of Medicine

The FDA has approved two medications for the treatment of eosinophilic esophagitis (EoE)—the first oral medication tailored for adults and the exclusive therapeutic option for children. Evan Dellon, MD, MPH, internationally known for his work with EoE, and colleagues continue to focus on optimizing usage for effective, personalized outcomes.

Released: 26-Feb-2024 9:05 PM EST
Clinical trial tests combination antibody therapy in adults with advanced cancer
Wiley

In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumor activity in individuals with various types of advanced cancer.

Released: 26-Feb-2024 1:05 PM EST
UChicago receives $13.2 million grant to test digital dementia intervention
University of Chicago Medical Center

Neuroscientist Emily Rogalski, PhD, is a principal investigator on a grant from the NIH to support a clinical trial of a telehealth intervention for primary progressive aphasia (PPA).

Released: 26-Feb-2024 12:00 PM EST
Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects
World Journal of Stem Cells

Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical sympt

Released: 26-Feb-2024 8:05 AM EST
First Drug to Help Reduce Allergic Reactions to Multiple Food Allergies, Tested at Children’s and Emory, Now FDA Approved
Children's Healthcare of Atlanta

Children’s Healthcare of Atlanta and Emory University participated in a nationwide clinical trial showing that a 16-week course of omalizumab, an injectable drug, increased the amount of peanut, tree nuts, egg, milk and wheat that some multi-food allergic children as young as one year could consume without an allergic reaction after exposure.

Released: 23-Feb-2024 1:05 PM EST
Researchers identify new choice of therapy for rare autoimmune disease EGPA
McMaster University

An international team, including researchers from McMaster University and St. Joseph’s Healthcare Hamilton, has identified a new therapeutic for patients with a rare autoimmune disease called eosinophilic granulomatosis with polyangiitis (EGPA). A biologic drug called benralizumab has been shown to be non-inferior to mepolizumab in the treatment of EGPA.

Newswise: Off-the-shelf vaccine offers hope for pancreatic and colorectal cancer patients with KRAS mutations
Released: 23-Feb-2024 10:05 AM EST
Off-the-shelf vaccine offers hope for pancreatic and colorectal cancer patients with KRAS mutations
University of California, Los Angeles (UCLA), Health Sciences

Samara Rahman, 74, enrolled in a clinical trial at UCLA Health that was evaluating an “off-the-shelf” vaccine that is given after surgery to prevent or delay the cancer from coming back in high-risk patients.

Newswise: New LongCOVID research launched by PolyBio's global consortium of scientists
Released: 22-Feb-2024 7:00 AM EST
New LongCOVID research launched by PolyBio's global consortium of scientists
PolyBio Research Foundation

PolyBio Research Foundation today announced the second phase of its LongCovid Research Consortium (LCRC), including the distribution of $15M to fund research and clinical trials.

Newswise: UNC Lineberger named as a national research hub for NIH cancer screening study
20-Feb-2024 12:05 PM EST
UNC Lineberger named as a national research hub for NIH cancer screening study
University of North Carolina Health Care System

UNC Lineberger Comprehensive Cancer Center has been selected as one of nine national research sites for the National Cancer Institute’s newly launched Cancer Screening Research Network, which will evaluate promising and emerging cancer screening technologies.



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