Although rheumatoid arthritis is an autoimmune disease with no cure, a tailored, multidisciplinary treatment approach at Cedars-Sinai鈥檚 Inflammatory Arthritis Clinical Center helps patients get back to the activities they enjoy.
Researchers have uncovered multiple new genes and genetic pathways that could lead to repurposing hundreds of existing drugs for osteoarthritis, the most common form of arthritis.
A study carried out at UdeM by Craig Turner and his doctoral supervisor Felipe Verdugo shows how pianists' "expressive intentions" may heighten their risk of long-term injury.
When menopause hits, your risk of bone fractures goes up. Penn State Health experts tell how to聽protect your skeleton (and deal with other menopause symptoms, too).
A recent study has revealed that KIAA1199, a secreted protein produced by bone marrow cells, plays a crucial role in regulating both fat formation and overall energy metabolism. The protein's impact extends beyond bone remodeling, influencing glucose and lipid metabolism. Mice lacking KIAA1199 showed reduced fat mass, improved insulin sensitivity, and a decreased risk of obesity-related diseases. These findings suggest that targeting KIAA1199 could lead to new therapeutic strategies for combating metabolic disorders like obesity and type 2 diabetes.
BACKGROUNDStem cells from apical papilla (SCAPs) represent promising candidates for bone regenerative therapies due to their osteogenic potential. However, enhancing their differentiation capacity remains a critical challenge. Enhancer of z
BACKGROUNDIn vivo degradation of bone scaffolds is significantly influenced by osteoclast (OC) activity, which is orchestrated by the interplay between receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG). T
In this editorial, we comment on the recent article by Xiao et al, focusing on their investigation into whether the therapeutic efficacy of serum-free human umbilical cord mesenchymal stem cells (MSCs) differs from that of serum-containing
PatientIQ, a leading health care technology company specializing in patient outcomes data, has expanded its support for national clinical registries with the launch of electronic health record (EHR)-integrated data submission for the American Spine Registry (ASR)鈥攁 collaborative effort between the American Association of Neurological Surgeons (AANS) and the American Association of Orthopaedic Surgeons (AAOS).
Cedars-Sinai Orthopaedics has appointed new leadership for its sports medicine program, further strengthening the medical center鈥檚 position as a premier destination for orthopedic care.
University Hospitals announced that Rikesh Patel, DO, a leader in total joint replacement and complex reconstruction of hip and knee, has accepted the position of Director of Robotics Surgery for Total Joint Replacement, effective immediately.
A new Harvey L. Neiman Health Policy Institute study found evidence that a new diagnosis of sarcopenia, a potentially reversible disease with low muscle mass and strength, often coincides with an abdominal CT study. Increasing opportunistic evaluation of abdominal CT scans could facilitate diagnosis of sarcopenia and ultimately improve patient care.
Sclerosteosis is a rare genetic disorder that causes excessive bone growth, leading to life-altering complications, including hearing loss and facial paralysis. In a promising new breakthrough, researchers have identified a drug called LGK974, which targets the Wnt signaling pathway by inhibiting the enzyme Porcupine.
Largest Genome-Wide Association Study Uncovers New Drug Targets and Potential Therapies for Osteoarthritis
Orthodontic treatments often take years, but a breakthrough discovery could drastically shorten this period. Researchers have uncovered that ATF6, a protein activated in macrophages during corticotomy, accelerates tooth movement by promoting inflammation and boosting the production of TNF伪, a key factor in bone remodeling. This finding paves the way for faster, more efficient orthodontic procedures, minimizing both treatment time and patient discomfort. The study highlights the potential for non-invasive therapies that could reshape the future of orthodontic care.
A recent study has uncovered a potential breakthrough in treating osteonecrosis of the femoral head (ONFH), a debilitating bone disease that causes severe pain and joint collapse. Researchers have discovered that exosomes derived from M2 macrophages-derived exosomes (M2-Exos) can significantly improve bone regeneration by modulating neutrophil extracellular traps (NETs) and endothelial cell function. These tiny vesicles, packed with miR-93-5p, were shown to reduce harmful NETs formation and enhance blood vessel growth, offering a novel therapeutic approach. This discovery highlights the potential of M2-Exos to address the root causes of ONFH, paving the way for non-invasive treatments that could prevent bone deterioration and improve patient outcomes.
Penn Medicine leaders and regional community representatives broke ground today on a four-story, 162,000-square-foot multispecialty outpatient facility that will expand options for patients to receive advanced care in Montgomery and Bucks counties.
Robert Barrack, MD, the Charles F. and Joanne Knight Professor of Orthopaedic Surgery at WashU Medicine, led a long-term study that showed that patients who received a Birmingham hip resurfacing procedure maintained a higher level of athletic activity years after their surgery than those who received a total hip replacement.
A new study conducted by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has uncovered a key mechanism behind lenalidomide resistance in multiple myeloma (MM), offering new insights into potential strategies for improving treatment outcomes and overcoming drug resistance.
Recent findings in bone regeneration research, highlights the significant impact of biological sex and donor variability on healing processes, offering promising new approaches to personalized medicine. By modeling cartilage-to-bone transition with innovative callus organoids, scientists discovered two distinct pathways鈥攈ypertrophic cartilage and fibrocartilage鈥攄riven by early progenitor cell activation.
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